Cagrilintide

Name: Cagrilintide
Availability: InStock

10mg vial

Cagrilintide is a long-acting analogue of human amylin, a pancreatic peptide co-secreted with insulin that regulates satiety, gastric emptying and post-prandial glucose excursions. It is studied both as a standalone investigational agent and in combination with GLP-1 receptor agonists for amplified weight-loss and glycaemic outcomes.

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Researched for

Potent appetite suppression via central amylin-receptor activation
Slowed gastric emptying and improved post-prandial glycaemic control
Synergistic weight-loss potential when combined with GLP-1 agonists
Reduced food cravings and improved portion control in research models
May preserve lean mass better than calorie restriction alone
Investigational cardiometabolic benefits beyond weight loss

Mechanism of action

Activates amylin receptors in the area postrema and other hindbrain nuclei to suppress appetite and reduce food intake. Also slows gastric emptying and modulates post-meal glucagon secretion, complementing the incretin effects of GLP-1-based therapies.

Research protocol

Common research protocols start at 0.3–0.6mg subcutaneously once daily, with gradual escalation based on tolerability. Cycles typically run 12–24 weeks. Subcutaneous administration in the abdomen, thigh or upper arm is standard.

Half-life

Extended half-life of several days due to acylation, supporting daily or less frequent dosing depending on formulation.

Reconstitution

Reconstitute a 10mg vial with 2–3mL bacteriostatic water for a 3.3–5mg/mL working concentration. Swirl gently - do not shake.

Storage

Lyophilised: 2–8°C, stable 18–24 months. Reconstituted: 2–8°C, protect from light, use within 28 days.

Research considerations

• Nausea, vomiting and constipation are common class effects, particularly during dose escalation.
• Hypoglycaemia risk increases when combined with insulin or sulfonylureas.
• Human safety data beyond Phase 2 remains limited; pancreatitis and gallbladder disease precautions mirror GLP-1 class.