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Wellness

Glutathione

600mg vial

Glutathione (γ-Glu-Cys-Gly) is the body's principal intracellular antioxidant and a critical cofactor for detoxification enzymes. It is studied for reducing oxidative stress, supporting liver function, modulating immune responses, and as an adjunctive skin-brightening agent through melanin-inhibiting mechanisms.

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Researched for

  • Master antioxidant activity across multiple cellular compartments
  • Phase II detoxification support and xenobiotic clearance
  • Immune-cell function and inflammatory balance modulation
  • Skin-brightening and melanin-modulating effects in research
  • Liver and mitochondrial protection under oxidative challenge
  • Replenishes levels depleted by ageing, stress and environmental toxins

Mechanism of action

Directly neutralises reactive oxygen species and regenerates other antioxidants (vitamins C and E). Serves as a substrate for glutathione peroxidase and glutathione S-transferase enzymes involved in phase II detoxification. In melanocytes, reduced glutathione shifts melanin production from eumelanin toward phaeomelanin.

Research protocol

Common research protocols use 200–600mg subcutaneously or intramuscularly per session, 1–3× weekly, or 600–1500mg weekly in divided doses. Skin-brightening research often uses higher-dose IV protocols under clinical supervision. Cycles typically run 4–12 weeks.

Half-life

Plasma half-life is short (minutes); intracellular pools replenish over hours to days with repeated dosing.

Reconstitution

Reconstitute a 600mg vial with 3–6mL bacteriostatic water for a 100–200mg/mL concentration. For 1500mg vials, 5–10mL is typical. Swirl gently - do not shake.

Storage

Lyophilised: 2–8°C, stable 12–18 months. Reconstituted: 2–8°C, protect from light, use within 14–21 days due to oxidation sensitivity.

Research considerations
  • Injectable and IV glutathione can cause sulphur-like taste or odour shortly after administration.
  • Asthma exacerbation has been reported in susceptible individuals.
  • Reconstituted glutathione oxidises over time; use promptly and protect from light.

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