PRODUCT INFORMATION UPDATED DAILY
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Skin

KLOW

80mg vial

KLOW is a research-grade compounded blend combining four complementary peptides - KPV (anti-inflammatory tripeptide), Larazotide (tight-junction modulator), Orexin-A (wakefulness and metabolic regulator) and GHK-Cu (regenerative copper tripeptide). Designed as a single-injection regenerative stack, it is studied primarily for gut-barrier integrity, systemic inflammation and skin/connective remodelling.

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Researched for

  • Combined gut-barrier, anti-inflammatory and regenerative activity
  • Single-injection convenience for stacked protocols
  • Skin and connective remodelling via the GHK-Cu component
  • Tight-junction support relevant to leaky-gut research models
  • Anti-inflammatory effect across NF-κB and α-MSH pathways
  • Daytime energy and appetite modulation via Orexin-A

Mechanism of action

GHK-Cu drives collagen synthesis and broad transcriptomic remodelling. Larazotide antagonises zonulin to tighten intestinal tight junctions. KPV provides α-MSH–derived anti-inflammatory activity via NF-κB suppression. Orexin-A modulates wakefulness, appetite and energy expenditure via OX1R/OX2R receptors.

Research protocol

Common research protocols use 200–500mcg of the blend subcutaneously once daily, typically morning administration due to the orexin component. Cycles run 4–8 weeks.

Half-life

Variable across constituents - GHK-Cu approx. 1 hour, KPV short, Larazotide local GI activity, Orexin-A approx. 30–60 minutes plasma.

Reconstitution

Reconstitute an 80mg vial with 4–5mL bacteriostatic water for approx. 16–20mg/mL working concentration. Swirl gently; the solution may appear faintly tinted due to the copper component.

Storage

Lyophilised: 2–8°C, stable 12–18 months. Reconstituted: 2–8°C, protect from light, use within 30 days.

Research considerations
  • Avoid evening administration - orexin component is wakefulness-promoting.
  • Compounded blends lack standalone clinical trial data; outcomes are extrapolated from constituents.
  • Avoid in copper-metabolism disorders (Wilson's disease) due to the GHK-Cu component.