5mg vial
KPV is the C-terminal tripeptide (Lys-Pro-Val) of alpha-melanocyte stimulating hormone (α-MSH). It retains the potent anti-inflammatory activity of the parent hormone without its pigmentation or appetite effects, and is studied across inflammatory bowel disease, dermatological inflammation, mast-cell modulation and wound healing.
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Enters cells and translocates to the nucleus to inhibit NF-κB activation, suppressing downstream pro-inflammatory cytokine production (TNF-α, IL-1β, IL-6). Also stabilises mast cells and modulates innate immune responses.
Common research protocols use 200–500mcg subcutaneously once daily, or higher oral/encapsulated doses (approx. 500mcg–1mg) for gut-targeted protocols. Cycles typically run 4–8 weeks.
Plasma half-life is short (approx. 30–60 minutes); local tissue effects persist longer.
Reconstitute a 10mg vial with 2–4mL bacteriostatic water for a 2.5–5mg/mL working concentration. Swirl gently.
Lyophilised: 2–8°C, stable 18–24 months. Reconstituted: 2–8°C, protect from light, use within 30 days.