10 vial
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH). It is a non-selective melanocortin receptor agonist studied primarily for stimulating melanin production (melanogenesis) in skin research models, with additional research interest in appetite regulation, energy homeostasis and sexual-function pathways.
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Agonises melanocortin receptors MC1R, MC3R, MC4R and MC5R. MC1R activation on melanocytes upregulates tyrosinase activity and eumelanin synthesis, increasing skin pigmentation. MC4R signalling in the hypothalamus mediates observed effects on appetite and energy expenditure, while MC3R/MC4R activity is linked to effects on sexual arousal pathways in research models.
Common research protocols use 250–500mcg subcutaneously once daily, often starting at 100–250mcg to assess tolerability before titrating upward. Loading phases typically run 2–4 weeks, followed by maintenance dosing of 500mcg–1mg one to two times weekly. Administering in the evening is common in research to minimise transient nausea.
Plasma half-life approx. 33 minutes; downstream melanogenic effects persist for days to weeks via sustained melanocyte stimulation.
Reconstitute a 10mg vial with 2mL bacteriostatic water for a 5mg/mL working concentration (500mcg per 0.1mL / 10 units on a U-100 syringe). Inject water slowly down the side of the vial and swirl gently - do not shake.
Lyophilised: refrigerate at 2–8°C (stable up to approx. 24 months); protect from light. Reconstituted: store at 2–8°C, protect from light, and use within 30 days.
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For research use only