MOTS-c

Name: MOTS-c
Availability: InStock

10mg vial

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene - one of a small class of mitochondrial-derived peptides (MDPs) that act as systemic metabolic signalling molecules. Endogenous MOTS-c declines with age and is correlated with insulin resistance, declining exercise capacity and metabolic dysfunction.

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Researched for

Improved insulin sensitivity in metabolic-syndrome animal models
Enhanced glucose homeostasis and lipid metabolism
Increased mitochondrial biogenesis and exercise capacity
Reduced adipose accumulation under high-fat-diet challenge
Cellular stress-resistance and longevity signals in preclinical work
Endogenous decline with age - replacement rationale in geroscience research

Mechanism of action

Activates AMPK, the master cellular energy-sensing pathway, driving glucose uptake, fatty-acid oxidation and mitochondrial biogenesis. Translocates to the nucleus under metabolic stress to modulate stress-response gene expression.

Research protocol

Common research protocols use 5–10mg subcutaneously 2–3× weekly, often timed pre-workout. Cycles typically run 4–8 weeks on / 4 weeks off.

Half-life

Plasma half-life is short (approx. 1–2 hours), but downstream AMPK-mediated effects persist over days.

Reconstitution

Reconstitute a 10mg vial with 1–2mL bacteriostatic water for a 5–10mg/mL working concentration. Swirl gently.

Storage

Lyophilised: 2–8°C, stable 18–24 months; -20°C for long-term. Reconstituted: 2–8°C, protect from light, use within 28 days.

Research considerations

• Human clinical data remains limited; most evidence is animal and in-vitro.
• Transient injection-site reactions possible.
• Effects on hypoglycaemia risk when stacked with insulin-sensitising agents are not well characterised.

Other peptides

CJC-1295 / Ipamorelin

Performance

Semaglutide

Metabolic