100mg vial
NAD+ (Nicotinamide Adenine Dinucleotide) is a fundamental coenzyme present in every cell, central to redox reactions, mitochondrial energy production, DNA repair and sirtuin-mediated longevity signalling. Cellular NAD+ levels decline substantially with age, and direct replenishment is a leading geroscience research target.
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Serves as a substrate for sirtuins (SIRT1–7), PARP DNA-repair enzymes and CD38, while functioning as an electron carrier in oxidative phosphorylation. Restoration of NAD+ levels reactivates downstream longevity, repair and metabolic pathways.
Common research protocols use 50–250mg subcutaneously or intramuscularly per session, 2–5× weekly. Higher-dose IV protocols (500–1000mg) are used in clinical research over 60–120 minute infusions. Start low - flushing and GI effects are dose-dependent.
Plasma half-life is short (minutes), but intracellular NAD+ pool replenishment persists for days.
Reconstitute a 500mg vial with 5–10mL bacteriostatic water for 50–100mg/mL. Reconstitute slowly down the side of the vial; the solution may appear faintly yellow.
Lyophilised: 2–8°C, stable 12–18 months; avoid freeze-thaw. Reconstituted: 2–8°C, protect from light, use within 14–21 days due to NAD+ instability in solution.