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Cognitive

Selank

5mg vial

Selank is a synthetic heptapeptide analogue of the immunomodulatory peptide tuftsin, developed at the Russian Institute of Molecular Genetics. It is studied for anxiolytic, nootropic and immunomodulatory effects, with a notably non-sedating profile and no benzodiazepine-style dependency liability in research.

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Researched for

  • Anxiolytic effect comparable to benzodiazepines in animal models without sedation
  • Upregulation of BDNF supporting neuroplasticity
  • Improved focus, working memory and stress resilience
  • No reported dependency, tolerance or withdrawal in research
  • Immunomodulatory effects relevant to viral and inflammatory research
  • Rapid onset, particularly via intranasal administration

Mechanism of action

Modulates GABA and serotonin systems indirectly, upregulates BDNF expression, and influences enkephalin metabolism via inhibition of enkephalin-degrading enzymes. Also exerts immunomodulatory effects via interleukin balance.

Research protocol

Common research protocols use 250–500mcg intranasally or subcutaneously 1–3× daily. Intranasal is the most common route. Cycles typically run 2–4 weeks of active use.

Half-life

Short plasma half-life (approx. 30 minutes), but functional CNS effects persist longer due to receptor-system modulation.

Reconstitution

Reconstitute a 5mg vial with 2–5mL bacteriostatic water (or sterile saline for intranasal use). Swirl gently.

Storage

Lyophilised: 2–8°C, stable 18–24 months. Reconstituted: 2–8°C, protect from light, use within 30 days.

Research considerations
  • Most clinical research originates from Russian-language literature; Western RCT data is limited.
  • Intranasal administration may cause transient irritation or taste changes.
  • Long-term safety beyond several months of continuous use is not well characterised.