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Performance

Tesamorelin

2mg vial

Tesamorelin is a stabilised 44-amino-acid GHRH analogue, FDA-approved as Egrifta for HIV-associated lipodystrophy. It produces a robust GHRH-driven GH/IGF-1 pulse and is the most clinically validated GHRH analogue for visceral adipose tissue (VAT) reduction without compromising subcutaneous fat or lean mass.

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Researched for

  • approx. 18% mean visceral adipose tissue reduction in Phase 3 (LIPO trials)
  • Improved IGF-1 levels and lipid profile in clinical research
  • Selective VAT loss without subcutaneous fat or lean mass loss
  • Preserved insulin sensitivity vs exogenous HGH protocols
  • Improved sleep architecture and recovery via natural GH pulse
  • Synergistic when stacked with Ipamorelin or other GHRPs

Mechanism of action

Binds pituitary GHRH receptors to stimulate endogenous GH synthesis and release, with downstream IGF-1 elevation. N-terminal modification protects against DPP-4 degradation, extending half-life vs native GHRH.

Research protocol

Standard research/clinical protocols use 1–2mg subcutaneously once daily, typically pre-sleep. Cycles typically run 12–26 weeks with reassessment. Often stacked with a GHRP (e.g. Ipamorelin) for amplified pulse synergy.

Half-life

approx. 25–40 minutes plasma; functional GH/IGF-1 elevation persists 12–24 hours.

Reconstitution

Reconstitute a 5mg vial with 1–2mL bacteriostatic water for a 2.5–5mg/mL working concentration. Swirl gently - do not shake.

Storage

Lyophilised: 2–8°C, stable 24 months. Reconstituted: 2–8°C, use within 14–28 days depending on diluent.

Research considerations
  • Injection-site reactions (redness, itching, swelling) are common.
  • Joint pain, peripheral oedema and paraesthesia reported in clinical trials.
  • Glucose tolerance should be monitored - modest insulin resistance can occur at higher doses.